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When HbA1c is considered unreliable — for example, due to B12 deficiency or anaemia — UK and WHO guidance recommends using a fasting plasma glucose test or a 75 g oral glucose tolerance test (OGTT) for diabetes diagnosis or assessment

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The caveat is that in human HCC, GNMT is frequently silenced, so it remains to be examined what the outcome of AdoMet treatment is when GNMT is not expressed