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Comprehensive illustration of NOX signaling is shown in Figure 5 , and the complete details on NOX isoform signaling mechanisms such as DUOX-1/IL-33 signaling, IL-13 signaling, NOX/Nrf-2 signaling, EGFR/ERK1 signaling, and PAR2/DUOX-2 signaling, are documented in the Supplementary Data of Supplementary Material