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UPS in skeletal muscle is activated after SCI, the breakdown of proteins in skeletal muscle after SCI is mainly accomplished through the ubiquitin-proteasome pathway (50, 150), resulting in greater catabolism than anabolism in skeletal muscle (151), in which the degraded proteins are covalently linked to ubiquitin molecules via the ubiquitin ligase complex, which is then processed by the 26S protease