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As a vital constituent of antigen-presenting cells (APCs), macrophage possesses two exact opposite-in-function phenotypes, M1 and M2, the former polarized by lipopolysaccharide (LPS), producing pro-inflammatory cytokines such as IL-1β, IL-6, IL-12, IL-23, and TNF-α, the latter polarized by Th2 cytokines, producing anti-inflammatory cytokines such as IL-10 and TGF-β [20]

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The consequences of pore opening depend upon its duration, where sustained activation leads to the collapse of ΔΨm, loss of ATP production, and ultimately cell death 137