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Workspace and Vial Preparation Before any vial is opened, the workspace should be clean and the equipment laid out within reach

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activation of the canonical, β-catenin-dependent pathway drives renal cell nuclear changes (Figure 3) towards an undifferentiated, proliferative state, while activation of the noncanonical pathway alters planar cell polarity [116–118], compared to normal renal tubular cells that divide parallel to the tubular lumen axis