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Position 2 (Alpha-aminoisobutyric acid, Aib) : The substitution of the natural amino acid at position 2 with the non-natural alpha-aminoisobutyric acid (Aib) residue is a well-established strategy for conferring resistance to dipeptidyl peptidase-4 (DPP-4) cleavage

VITAMIN B12

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doi:10.1016/S0021-9258(20)78281-5 ^ Burr G.O., Burr M.M., Miller E.S