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34 These mechanisms may also reduce adhesion after abdominal surgery 35 and limit the replacement of functioning connective tissue with fibrotic tissue in autoimmune diseases

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From the longitudinal studies on diabetes care, it was determined that once diabetes is established, A1c control alone may not prevent complications of diabetes due to long-lasting epigenetic changes that drive persistent expression of pro-inflammatory genes after glycemia is normalized, known as “hyperglycemic memory” [93]