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While NPs like salvianolic acid show preclinical antifibrotic activity, their undefined targets and pharmacokinetics hinder clinical adoption—a stark contrast to approved synthetics like pirfenidone (2,403 mg/day) (Noble et al., 2011) and nintedanib (300 mg/day) (Richeldi et al., 2014), which themselves face tolerability limitations (Raghu et al., 2022a)
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