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Thus, these data suggest that the ability of LRRC58 to restrain cysteine catabolism via CDO1 degradation is necessary to prevent ferroptotic cell death under conditions of cysteine scarcity

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Instruct patients to promptly report any unexplained muscle pain, tenderness or weakness particularly if accompanied by malaise or fever [see Warnings and Precautions (5.1), and Drug Interactions (7.1)]