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In mice, the authors demonstrated that PHGDH interacts with phosphofructokinase, and the loss of this interaction increases flux through hexosamine biosynthesis ( V Ξ² 3 sialylation, which facilitates tumor metastatic activity
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10.1038/sj.onc.1203859 38 GaoS.ZhaoZ.WuR.WuL.TianX.ZhangZ
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