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In the first-in-human study, an intermittent regimen of 260 mg once daily (Days 1–3 and 15–17 of a 28-day cycle) was established, mitigating dose-limiting hematologic toxicity while maintaining activity compared with continuous dosing [282]

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Their specificity — the ability to bind to particular receptors and trigger precise downstream events — is what underpins their therapeutic potential in targeted drug delivery, often identified through phage display, and is why they have become a cornerstone of modern peptide research