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Such variability surrounds many aspects of AOX therapy including pre-testing the patient for OS, the choice of a specific AOX or AOX combination, proper dose, optimum duration of therapy and the desired outcome

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In four-week-old male weanling C57BL/6J mice treated with 25 or 50 ppm of sodium arsenite and high-fat-diet (HFD) for 20 weeks resulted in an increased glucose intolerance and decreased insulin secretion in dose-dependent manner compared with mice only exposed to HFD (32)