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This multi-omics-driven organoid platform not only validates the effectiveness of drug targets but also predicts drug-metabolite interaction networks through metabolomics analysis, providing a theoretical basis for dose design in subsequent clinical trials (Zou et al., 2021), discovering that epigenetic regulatory factors (such as Histone Deacetylases) may become synergistic targets to enhance drug sensitivity (Ramaiah et al., 2021)

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The Panel noted that the P95 exposure estimates for chronic exposure to saccharins (E 954), expressed as free imide, were below the ADI of 9 mg/kg bw per day in all populations