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Retained eggs elicit granulomatous inflammation and progressive immune-mediated pathology, ultimately leading to chronic hepatic fibrosis ( The chronic immune response, dominated by a Th2-mediated reaction, leads to fibrosis, hepatomegaly, and portal hypertension ( schistosomes ( Schistosoma japonicum –induced liver fibrosis through NF-κB–dependent signaling pathways

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doi: 10.1002/glia.22437