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4 Discussion In this study, we found that EA alleviated cognitive impairment in VaD mice by regulating cholinergic vasodilation system, which involves activating cholinergic neurons, increasing ACh release in basal forebrain, up-regulating m-1AChR in frontal cortex, promoting eNOS expression, enhancing NO release, and promoting cerebral arterioles dilation

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Physical therapy : Physical therapy that helps to improve hip range of motion, strength, and stability are also recommended