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Additionally, oxidative stress, lipid peroxidation, and iron homeostasis imbalance exacerbate the aggregation of Htt with other proteins, leading to increased glutamate excitotoxicity, disrupted mitochondrial function, altered autophagy mechanisms, impaired axonal transport, and ultimately neuronal degeneration, thereby causing the motor, cognitive, and behavioral symptoms of HD (Reichert et al., 2020)
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