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What has been the response to leucovorin on children with Autism that I see. It has been pretty amazing literally like an awakening- the child is more aware, focused, better eye contact, seems to be ...

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These results demonstrate that, while compound 1 does not directly engage HRAS and NRAS in their native form, the chemical mechanism to promote GTP hydrolysis is likely applicable to a variety of oncogenic Q61X mutants once suitable ligand scaffolds are identified