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The first group considered at high risk for severe B12 defi­ciency had serum B12 287pmol/L and a median methyl­malonic acid concen­tration of 120nmol/L, while the third group was classified as indeterminate and difficult to interpret with an intermediate serum B12 (126‑287pmol/L)

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Clinical applications address COPD support (10 nanomolar concentration in research restored lung fibroblast function), acute injury recovery (reduced inflammatory cell infiltration in lung injury models), and general tissue regeneration (systemic administration improved healing at distant body locations)