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For many aldehydes, relative electrophilicity (ω) is a useful predictor of toxic potential because the mechanistic basis of their toxicity involves the rate of covalent adduct formation reactions with various macromolecules
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In pasireotide, cyclization between the N- and C-termini extends its half-life to 12 h, making it particularly effective for treating Cushing’s disease compared to other somatostatin analogues (Figure , Table )
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