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Crystal nephropathy can occur as a result of endogenous or exogenous factors, such as hyperuricemia, hyperoxaluria, or drug administration [30]

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We would expect that any decrease in total cytosolic thiol concentrations, either through their oxidation or through a decrease in total thiol levels, leads to increased buffered available cytosolic concentrations of Zn 2+ , similar to a situation in which excess Zn levels are present in the cytosol (Box 1.5, Figure 2a–c)