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Acknowledgements The authors acknowledge support from the National Natural Science Foundation of China (grant numbers 42206208, 42261134536, 42076208), the International Partnership Program of the Chinese Academy of Sciences (grant no

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GHK-Cu is a copper-binding tripeptide widely explored for its involvement in extracellular matrix signaling and biomarker modulation in skin and connective-tissue research models, and KPV is a short peptide fragment associated in preclinical literature with immunomodulatory and inflammation-linked pathway investigation