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The finding that higher BBB permeability is associated with reduced Alzheimer's risk for those taking βBs favours the hypothesis that these medications confer a protective effect that may be independent of their capacity as antihypertensives, if they are able to cross the BBB and reach the site of Alzheimer's disease pathogenesis

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Damage to the nervous system is one example of additional tissue metabolism issues that might arise.When used together, the two are particularly successful at supplying iron deficient animals