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Ballard and colleagues (Growth Regulation, 1993) reported that IGF-I binds IGFBP-3 with roughly one thousand times the affinity of LR3IGF-I, and Wilson and colleagues (2000) found that, unlike IGF-I, the Long R3 variant did not raise serum IGFBP-3 in adolescent monkeys

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[DOI] [Google Scholar] 123.Luo S., Fan L., Yang K., Zhong Z., Wu X., Ren T