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Phase IIb OPTIONS trial (2006 to 2007) — the definitive result: The larger and more rigorous 24-week Phase IIb trial enrolled 536 obese subjects randomized to receive 0.25, 0.5, or 1 mg/day oral AOD-9604 or placebo
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This happened through mitochondrial protection and decreased ROS production in rat models with chronic cerebral hypoperfusion
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