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some libido effects FDA approval PT-141 (bremelanotide) Yes - Vyleesi for premenopausal women with HSDD Sildenafil / Tadalafil Yes - erectile dysfunction (men) Melanotan II No - not FDA-approved for any indication Route PT-141 (bremelanotide) Subcutaneous injection (or investigational intranasal) Sildenafil / Tadalafil Oral Melanotan II Subcutaneous injection Combination notes PT-141 (bremelanotide) Should not combine with Melanotan II (same receptor family) Sildenafil / Tadalafil No formal combination data with PT-141 Melanotan II Should not combine with PT-141 Comparison reflects regulatory and mechanistic differences, not a recommendation