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The presence of PN in PD subjects has been found to be associated with various factors in two large studies, including the total dosage of LDopa, low serum Vit B12 levels, and elevated Hcy and MMA levels (Ceravolo et al
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In this study, participants were randomised to placebo ( n = 27) or a twice-daily capsule of 50 mg of thiamine, 20 mg of riboflavin, 100 mg of niacin, 163.5 mg of pantothenic acid, 30 mg of pyridoxine, 500 µg of folate (B9), 500 µg of cyanocobalamin, 500 µg of biotin, 100 mg of choline and 500 µg of inositol ( n = 35)
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