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Key research questions are identified and systematically reviewed such as: (i) what are the key factors responsible for the dysregulation of mtROS production

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An over-the-counter oral antihistamine like cetirizine (Zyrtec), loratadine (Claritin), or diphenhydramine (Benadryl) reduces histamine activity systemically and can relieve injection site itching within 30 to 60 minutes