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In contrast, the DOX group exhibited severe myocardial injury characterized by myofibrillar degeneration, cytoplasmic vacuolization, necrosis, and marked inflammatory cell infiltration

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Under starvation conditions, the simultaneous inactivation of mTORC1 and dephosphorylation of MiT/TFE proteins by the phosphatase Calcineurin permits their nuclear entry [23]