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(1) oxidative folding, which is common and depends on the protein folding pathway conferring the correct disulfide connectivities under thermodynamic control (e.g., the correct isomer out of the 75 possibilities for three disulfide bonds)
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In a 3D model of MCF7-HER2 culture, an increased level of HIF-2α was reported to be present outside the hypoxic regions of spheroids [22]
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