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Fluorometry studies and post-mortem toxicological analysis have shown that transfer of molecules from systemic circulation into vitreous are mediated by diffusion, hydrostatic and osmotic pressure gradients, convection, and active transport, through the blood-aqueous and blood–retina barriers [30,98,179,180,181]

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Pathological astrocytes, when mixed with healthy neurones, can, on their own precipitate neuronal death, again indicating a leading role of astrocytes in pathophysiology of ALS

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