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This assumption was validated by clinical experts as reasonable (Geoffrey Liu, MD, telephone communication, June 24, 2020) Treatment-related hospitalization would occur only in patients with severe toxicities Approximately 1% to 2% of DPYD tests would fail (e.g., issues with DNA extraction, reaction failure, etc.) and need to be re-run (Richard Kim, MD, email communication, February 20, 2020

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6 In contrast, the pathogenesis of halogen-induced acne includes activation of intracellular aryl hydrocarbon receptor, which activates cytochrome p450 1A1 leading to comedogenesis