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doi.org/10.1080/15569543.2018.1514637

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Mechanistically, IDO-1 triggers cell cycle arrest at the G1 phase, or induces autophagy in T cells by activating the amino acid-sensitive kinase GCN2 35 , and by inhibiting the mTOR signaling pathway via the tryptophan–kynurenine metabolic pathway in the tumor microenvironment