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Maximum Responder Rate (20%+ Loss)# Recommendation : CagriSema Reason : 60% of CagriSema patients achieved at least 20% weight loss in REDEFINE 1, a higher responder rate than tirzepatide's across-trial data, though cross-trial comparison has limitations

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The C57BL/6J mouse strain has a null mutation of the Nnt gene that influences diet-induced obesity (Nicholson et al., 2010;), but his mutation is not present in the C57BL/6NJ substrain (Kane et al., 2017)