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LPA-driven EMT utilizes various upstream cues, including the Wnt/β-catenin, PI3K-Akt, Notch, and HIF-1α-Src axes, but converges on transcriptional regulators such as Snail, Slug, Twist, and ZEB1, which orchestrate epithelial suppression and mesenchymal transition, enabling cellular plasticity and metastatic potential