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Additionally, peroxynitrite oxidizes tetrahydrobiopterin, an essential cofactor for eNOS, rendering it biologically inactive and unable to catalyze endothelial NO synthesis [15]

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A phase 2 study reported an improved median overall survival (mOS) when nimotuzumab was combined with radiation in patients with high-grade glioma, showing a mOS of 17.76 months compared to 12.63 months in the placebo plus radiation group (23)