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The complete knockout of ERCC1 has been observed to result in a lifespan of 3–4 weeks, while the hypomorphic variant ERCC1 − /Δ , which preserves 10% of protein expression, has been found to exhibit a lifespan of 7 months 66,136

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Questions such as morning versus evening, before exercise, daily versus non-consecutive days, or two-week versus twelve-week cycles are not answered by published human dosing trials