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Future clinical studies with data safety and monitoring are warranted to determine whether these antioxidant micronutrients may act individually or in synergy as a nonpharmacological means of prevention and treatment

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Initially, ferritin accrues iron atoms in the ferrous form, which are then oxidized to ferric iron by the ferroxidase center of H-ferritin, located in the interior of the ferritin cavity (reviewed in The role of PCBP1 in the mineralization of ferritin was initially identified through functional screening of a human liver cDNA library in a eukaryotic model lacking endogenous ferritin expression, i.e., Saccharomyces cerevisiae (Shi et al., 2008)