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Additionally, some research suggests chronic GLP-1 agonist use may reduce gastric acid secretion over time, though this finding remains controversial

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Several diseases of aging are linked to accumulation of specific pathological protein aggregates, such as Alzheimer’s disease, where extracellular amyloid plaques and intracellular tau are disease drivers, or senile amyloidosis, where polymerization of transthyretin proteins causes tissue dysfunction in the heart and nervous system among other tissues (197, 205, 206)