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A positive correlation has also been shown between MTHFR mutations and rheumatoid arthritis More recently it has been shown the many people with Chronic Fatigue Syndrome (CFS/ME) have methylation mutations Apart from the formation of methylated myelin basic protein, the are over 200 methylation reactions in the body including the production of creatine (involved in energy production), CoQ10 (an essential electron shuffle vector in the electron transport chain), carnitine (involved in uptake of fatty acids into mitochondria), the production of phosphatidyl-choline, adrenalin, melatonin (essential for neuronal development, gut health, and sleep),myelin basic protein, methylation of lysine, histidine and arginine, and in the inactivation of histamine, dopamine, nor-adrenalin, and adrenalin, amongst others
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