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These in vivo and in vitro studies were carried out with mice lacking the nuclear factor erythroid 2-related factor-2 ( Nrf2 ), whose gene product is a redox-sensitive transcription factor that is crucial to the regulation of the antioxidant defense system [54,55]

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In melanoma brain metastasis, multi-omics analysis displayed significant enrichment of OXPHOS and the TCA cycle [132]