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Modern biologics include adalimumab, secukinumab (IL-17A), ixekizumab (IL-17A), brodalumab (IL-17RA), guselkumab (IL-23p19) and risankizumab (IL-23p19) — the IL-23 class delivering the highest PASI 100 response rates across head-to-head trials (Reich et al., Lancet 2019)
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