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A mucoadhesive film containing curcumin was tested for aphthous ulcers–patients applied the patch to the ulcer and left it in place, where it dissolved over ∼30 min, delivering curcumin into the ulcer site
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We demonstrated that overcoming this limitation through exogenous supplementation of nitric oxide, a molecule whose production otherwise is reduced in high-grade PCa, can reinstate the S-nitrosylation of MYCN at specific sites (Cys4, Cys186, Cys46)
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