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Subsequently, PGD 2 and PGE 2 are metabolized to 11,15-dioxo-9α-hydroxy-2,3,4,5-tetranorprostan-1,20-dioic acid (i.e., tetranor-PGDM) and 9,15-dioxo-11α-hydroxy-2,3,4,5- tetranorprostan-1,20-dioic acid (i.e., tetranor-PGEM), respectively (Fig

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Both the size of the circle and colour represent the specificity of that alteration to the basal-like subtype, with a larger circle and darker colour indicating greater specificity