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A study conducted in 2016 thus came to the following conclusion: “If we had restricted the treatment of symptomatic patients to patients with both low serum levels and elevated metabolite levels, 63% of patients who responded well to the therapy would not have received treatment […] Only 16% of patients with good clinical improvement from vitamin B12 therapy had low serum levels and 54% of patients with good clinical improvement from vitamin B12 therapy had serum levels higher than 300 pg/mL.” Some experts thus advise high-dose B12 treatment to treat all known nervous symptoms associated with B12 deficiency

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started in 2013 where they administered 1000 µg methylcobalamin subcutaneously around the torso once every morning six times a week for a total of four weeks ( N = 33)