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327 CR may prevent AD by lowering serum tyrosine levels to reverse the exhaustion of tyrosyl-tRNA synthetase (TyrRS) and upregulating the sirtuin pathway, which attenuates the amyloidogenic processing of amyloid-β protein precursor (APP), as confirmed by in vivo and in vitro models

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Senolytic compounds can act by inhibiting these proteins, promoting cell death in senescent cells.51,52 For instance, navitoclax (ABT-263), venetoclax, and ABT-737 are BCL-2 inhibitors that disrupt pro-survival signaling, leading to senescent cell death