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The loss of the outer CSD of ERO1B in land animals may have resulted in decreased inhibition, allowing these organisms to cope with the greater demands for disulfide bond formation in their secretory organs

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Furthermore, Keap1, a cysteine rich protein which binds to NRF2 and regulates oxidative and electrophilic stress, was co-localized with intracellular misfolded protein inclusions in motor neurons in the spinal cord of ALS patients