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While there is general agreement in the literature that APAP-induced cell necrosis causes DAMP release, proinflammatory mediator formation, and recruitment of inflammatory cells into the liver, it is highly controversial whether this sterile inflammatory response actually aggravates the injury or is beneficial by removing cell debris and promoting regeneration111–113 (Fig

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Complications of endoscopic retrograde cholangiopancreatography in primary sclerosing cholangitis