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Gut microbiota modulates this process through leptin sensitivity regulation: probiotics predominantly comprising Lactobacillus and Bifidobacterium species significantly reduce serum leptin levels by mitigating endotoxemia and improving adipocyte secretory profiles (López-Moreno et al., 2020)

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Additionally, this study observed heightened expression of NLRP3, GSDMD, and cathepsin D (CTSD) in human bronchial epithelial cells infected with lentivirus overexpressing ORMDL3