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Research demonstrates that TB-500 forms functional complexes with PINCH-1 and integrin-linked kinase (ILK) that can inhibit TNF-α-induced NF-κB activation through blocking RelA/p65 translocation, providing rapid suppression of inflammatory transcriptional programs

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But such joint replacement is extremely invasive, has a limited lifespan and is performed only after arthritis hits and patients endure lasting pain