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Mtb is continually exposed to endogenous reactive oxygen species (ROS) as part of normal aerobic respiration, as well as exogenous ROS and reactive nitrogen species (RNS) generated by the host immune system in response to infection
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PARP inhibitors have also shown significant synergy with type I PRMT inhibitors in NSCLC and in ovarian cancer, where type I PRMT inhibition re-sensitised resistant PEO4 ovarian cancer cells to PARP inhibitor treatment in vitro (112)
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